Maternal Cell Contamination Study, STR Analysis
Also known as: Fetal Cell Contamination, Fetal Sample Contamination
Use
This test is used to assess whether a prenatal genetic result (for example, from amniotic fluid or chorionic villi sampling) is contaminated with maternal cells. It ensures that a fetal result truly reflects fetal DNA, by comparing microsatellite (STR) profiles of the prenatal specimen and maternal blood; appropriate inheritance of maternal alleles provides assurance of fetal origin. It is commonly used in conjunction with prenatal molecular genetic testing to confirm results accurately and avoid misinterpretation due to maternal contamination.
Special Instructions
A separate specimen of maternal whole blood (EDTA tube) is required to perform the comparison. It is typically ordered in conjunction with prenatal testing. Instructions advise contacting Quest Genomics Client Services (1‑866‑436‑3463) when ordering to coordinate specimen collection. Counseling and informed consent are recommended for genetic testing.
Limitations
The test should not be used as a standalone tool for diagnosis or to replace primary prenatal testing; maternal cell contamination must be evaluated alongside other prenatal results. Analytical sensitivity and interpretation depend on clear allele inheritance patterns; ambiguous or poor-quality samples may limit conclusive results. The reproducibility and analytical performance have been internally determined by Quest Diagnostics, and an FDA review or clearance for this test is not indicated in public information.
Methodology
PCR-based (Multiplex PCR)
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
EDTA (lavender-top) tube
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