Methemoglobinemia Interpretation
Use
This test is useful for the interpretation of methemoglobinemia evaluation results, diagnosis of methemoglobinemia and sulfhemoglobinemia, and identification of possible hereditary (congenital) causes. It aids in the differentiation of methemoglobinemia and sulfhemoglobinemia from other causes of cyanosis, such as congenital heart disease. The test involves a consultative evaluation by a hematologist expert in these disorders, who reviews history and previous laboratory values and issues an interpretive report.
Special Instructions
Not provided.
Limitations
Methemoglobin is unstable and can degrade at a rate of about 40% per 24 hours, potentially affecting results if specimens are stored or shipped improperly. A normal methemoglobin value in stored or shipped specimens does not exclude prior minor methemoglobinemia. Sulfhemoglobin is stable and persists until the erythrocytes containing it are destroyed, as it cannot combine with oxygen. Some hemoglobin variants may interfere with this test, and sulfhemoglobin absorbance can be increased by hemoglobin variants.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 59466-3 - Hematologist review
- 59465-5 - Path Rev
- 18771-6 - Provider signing name
Result Turnaround Time
3-25 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
Not provided
Minimum Volume
Not provided
Container
EDTA tube
Storage Instructions
Refrigerate specimen and ensure it is delivered within 72 hours.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 72 hours |