Methylmalonic Acid, Quantitative, Urine
Use
Evaluating children with signs and symptoms of methylmalonic acidemia using urine specimens. Evaluating individuals with signs and symptoms associated with a variety of causes of vitamin B12 (cobalamin) deficiency.
Special Instructions
None noted in provided content.
Limitations
Diet, nutritional status, and age should be considered in the evaluation of serum or urine methylmalonic acid level. In pediatric patients, markedly elevated methylmalonic acid values indicate a probable diagnosis of methylmalonic acidemia and require additional confirmatory testing; in adults, moderately elevated values indicate a likely vitamin B12 deficiency.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 25116-5
- 25116-5
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
4 mL
Minimum Volume
1.2 mL
Container
Plastic, 10‑mL urine tube
Collection Instructions
After fasting at least 8 hours overnight, patient should void first‑morning urine as normal (do not collect), then collect the next (second morning) urine.
Patient Preparation
Fasting: 8 hours, required
Storage Instructions
Store frozen preferred; refrigerate OK.
Causes for Rejection
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 21 days |
| Refrigerated | 28 days |
| Frozen | 28 days |