Methylmalonic Acid, Serum or Plasma
Use
Serum methylmalonic acid (MMA) measurement is used to evaluate individuals with signs and symptoms associated with vitamin B12 deficiency1-7 or congenital methylmalonic academia.8,9
Special Instructions
MMA concentrations are often elevated in early stages of vitamin B12 deficiency while serum levels remain normal. Follow-up measurement can help assess vitamin B12 supplementation effectiveness.
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. Plasma from a light blue-top or yellow-top tube is unsuitable as citrate interferes with the assay.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 13964-2
- 13964-2
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.6 mL
Container
Red-top tube, gel-barrier tube
Collection Instructions
Separate serum or plasma from cells within one hour of collection.
Storage Instructions
Refrigerate.
Causes for Rejection
Plasma from a light blue-top or yellow-top tube; citrate interferes with assay
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 19 days |
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