MLH1, IHC with Interpretation
Also known as: MMR=mismatch repair, Hereditary Nonpolyposis Colon Cancer (HNPCC), Lynch Syndrome
Use
This immunohistochemistry (IHC) assay is based on an antibody directed against the DNA mismatch repair (MMR) protein MLH1; it detects the presence or absence of MLH1 protein expression in tumor tissue which can aid in identifying Lynch syndrome and assessing MMR deficiency.
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Immunoassay (IHC)
Biomarkers
MLH1
Protein
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tumor Tissue (Fixed (Non-FFPE))
Volume
Not provided
Minimum Volume
Not provided
Container
Formalin-fixed paraffin embedded tissue in an IHC specimen transport kit; or 4‑micron unstained slides (x5); fixed tissue in neutral buffered formalin
Collection Instructions
Pathology report is required
Storage Instructions
Room temperature indefinite
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinite |
| Refrigerated | Indefinite |
| Frozen | Unacceptable |
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