Use

Human mismatch repair protein 2 (MSH2) is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Loss of MSH2 function leads to the accumulation of replication errors, which in turn may be responsible for the multiple mutations required for multistage carcinogenesis. Mutations in the MSH2 gene are linked to hereditary nonpolyposis colon cancer and to sporadic cancers that exhibit microsatellite instability.