Multiple myeloma oncogene 1
Use
Multiple myeloma 1 (MUM1) is normally expressed in plasma cells, activated B cells, and activated T cells. Translocation to the Ig heavy chain locus is commonly observed in multiple myeloma causing consistent MUM1 expression. MUM1 is also found in a range of lymphoid neoplasms, including a proportion of diffuse B cell lymphomas, Reed Sternberg cells in Hodgkin's disease, and neoplastic T cells.
Special Instructions
Fresh tissues should be fixed in formalin for 24-72 hours by collection sites, then transferred to 70% ethanol and stored at 2-8°C for longer-term storage if needed. Unstained slides require positively charged glass slides to prevent background staining and tissue loss. Slides should be left unbaked.
Limitations
Specimens must be fixed in 10% Neutral Buffered Formalin (NBF) or B plus; all other fixatives will be rejected. Stated Turnaround Times (TATs) are for clinical use only and may change based on biopharma protocol requirements.
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
2-null days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fixed (Non-FFPE))
Volume
Not provided
Minimum Volume
Not provided
Container
Fixative at 20:1 fixative to tissue ratio, 10% neutral buffered formalin for 6-72 hours (48-72 hours preferred)
Storage Instructions
Store at 15°C to 25°C
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | Indefinite |