Myelodysplastic Syndrome (MDS), Diagnostic FISH, Varies
Use
This test is useful for detecting recurrent common chromosome abnormalities associated with myelodysplastic syndromes (MDS) or other myeloid malignancies using a panel of FISH probes. It serves as an adjunct to conventional chromosome studies in patients with MDS and is helpful for evaluating specimens in which chromosome studies are unsuccessful. The test also aids in identifying and tracking known chromosome abnormalities in patients with MDS and monitoring their response to therapy.
Special Instructions
If this test is ordered alongside a chromosomal study (CHRBM or CHRHB), testing will be held pending chromosome test results. If results are complete and informative, this test will be canceled. If a complete chromosome study is not achieved, this test will proceed. The test should not be used to screen for residual MDS; in that case, the MDSMF test is more appropriate.
Limitations
This test is not approved by the US FDA and should be used as an adjunct to existing clinical and pathological information. FISH is not a substitute for conventional chromosome studies as it does not detect chromosome abnormalities associated with other hematological disorders that may not be included in the panel. The absence of an abnormal clone does not rule out the presence of a neoplastic disorder.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 62367-8
- 50397-9
- 69965-2
- 93356-4
- 62356-1
- 42349-1
- 31208-2
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 to 3 mL
Minimum Volume
1 mL
Container
Yellow top (ACD); Acceptable: Green top (sodium heparin) or lavender top (EDTA)
Collection Instructions
It is preferable to send the first aspirate from the bone marrow collection. Invert several times to mix bone marrow. Send bone marrow in original tube. Do not aliquot.
Causes for Rejection
Fresh tissue: Reject