NeoTYPE® Precision Profile for Solid Tumors
Also known as: Solid Tumor Profile, Precision Profile
Use
This test analyzes 83 biomarkers utilizing a combination of next-generation sequencing (NGS) and immunohistochemistry (IHC). The test provides a summary interpretation of all results to guide treatment decisions for patients. Reflex testing is available, including NTRK NGS Fusion Panel and MSI by PCR, depending on initial results, and is designed to better understand the genetic profile of solid tumors.
Special Instructions
If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of 'indeterminate' will create a reflex to MSI by PCR based on specific tumor percentage requirements for colorectal and non-colorectal specimens.
Limitations
Results interpretation may be affected by factors such as sample quality, tumor heterogeneity, and the presence of interfering substances. The test does not detect all genetic variants and is limited to the specified set of biomarkers. Reflex tests can extend turnaround times and are based on initial findings and tumor characteristics.
New York Approved
Methodology
NGS (Targeted)
Biomarkers
Result Turnaround Time
14 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Paraffin block is preferred. Please use positively-charged slides and 10% NBF fixative.
Storage Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
Causes for Rejection
Do not use zinc fixatives.