Neurochondrin Antibody, Tissue Immunofluorescence Titer, Serum
Use
The Neurochondrin Antibody, Tissue Immunofluorescence Titer, Serum test is useful for detecting neurochondrin-IgG in serum from patients presenting with cerebellar and brainstem syndrome. Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration. Patients positive for neurochondrin-IgG often present with subacute to chronic cerebellar and brainstem syndrome and may benefit from long-term immunosuppressive treatment, potentially leading to clinical stabilization or improvement.
Special Instructions
This test is only orderable as a reflex. If the indirect immunofluorescence pattern suggests neurochondrin, this test and the neurochondrin antibody cell-binding assay will be performed at an additional charge. It must be ordered in conjunction with autoimmune/paraneoplastic evaluation tests, such as DMS2, ENS2, EPS2, MAS1, MDS2, or PCDES.
Limitations
A negative result does not exclude neurological autoimmunity or cancer. Interference by coexisting non-neuron-specific autoantibodies can typically be eliminated by serologic absorption. Additionally, cancers are generally not detected, despite the paraneoplastic basis being considered, especially in women with uterine cancer.
New York Approved
Methodology
Immunoassay (Indirect Immunofluorescence Assay (IFA))
Biomarkers
LOINC Codes
- 101454-7
Result Turnaround Time
5-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
Not provided
Causes for Rejection
Gross hemolysis, Gross lipemia, Gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |