Neuron-Specific Enolase, Serum
Use
The Neuron-Specific Enolase (NSE) test is useful as a follow-up marker in patients with NSE-secreting tumors of any type. It serves as an auxiliary test in the diagnosis of small cell lung carcinoma, carcinoids, islet cell tumors, and neuroblastomas. Additionally, it can be an auxiliary tool in assessing comatose patients, where elevated serum concentrations suggest poor outcomes.
Special Instructions
Specimens should not be transported by tube system prior to centrifugation. Centrifuge and aliquot serum into a plastic vial before shipment or storage.
Limitations
All neuron-specific enolase (NSE) test results must be considered in the clinical context. Interferences or artifactual elevations should be suspected if the clinical NSE test results do not align with the clinical picture or other tests. Hemolysis can lead to significant artifactual NSE elevations as erythrocytes contain NSE, and hemoglobin concentrations as low as 20 mg/dL can adversely affect testing. Other conditions such as proton pump inhibitor treatment, hemolytic anemia, hepatic failure, and kidney failure may also result in artifactual elevations. NSE levels can vary significantly between methods/assays; serial follow-up should be performed with the same assay.
New York Approved
Methodology
Immunoassay (Other)
Biomarkers
LOINC Codes
- 15060-7
- 15060-7
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Plastic vial
Collection Instructions
Specimens should not be transported by tube system prior to centrifugation. Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis; Hemolysis at any level; Gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 5 days |
| Refrigerated | 7 days |