Nickel, Urine

Casandra

Casandra Test Code AR43783Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0025045CPT Code 83885

Clinical Use

Use

Measurement of nickel in urine is used to assess exposure to nickel. This test is not recommended for asymptomatic individuals or those with a low likelihood of exposure. Elevated levels might suggest contamination from skin or the collection process, especially if non-certified trace element-free containers are used.

Special Instructions

Not provided.

Limitations

Results can be contaminated by non-trace element-free containers, blood, fecal material, or urine collected within 48 hours of gadolinium-containing contrast media administration. Acid-preserved urine is unacceptable. Elevated results might be due to contamination rather than true nickel exposure.

Test Details

New York Approved

Methodology

Mass Spectrometry

Biomarkers

5 targets

Creatinine, Urine - per 24hCreatinine, Urine - per volumeNickel, Urine - per 24hNickel, Urine - per volumeNickel, Urine - ratio to CRT

LOINC Codes

Result Codes

35674-1 - Creat ?Tm Ur-mCnc
2162-6 - Creat 24h Ur-mRate
29936-2 - Nickel 24h Ur-mCnc
30933-6 - Nickel ?Tm Ur-mCnc
5705-9 - Nickel 24h Ur-mRate
19153-6 - Specimen vol ?Tm Ur
30211-7 - Specimen collect Time Spec

Result Turnaround Time

1-8 days

Specimen

Urine

Volume

Not provided

Minimum Volume

1 mL

Container

ARUP Trace Element-Free Transport Tubes

Collection Instructions

24-hour or random urine collection. Specimen must be collected in a plastic container. Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes.

Patient Preparation

Abstain from iodine-containing drugs or contrast a month prior. Discontinue nonessential medications and supplements upon advice.

Storage Instructions

Refrigerated transport recommended. Room temperature and frozen also acceptable.

Causes for Rejection

Urine collected within 48 hours of gadolinium-containing contrast media. Acid-preserved urine, and specimens contaminated with blood or fecal material. Non-trace element-free transport tubes are unacceptable.