NSE (Neuron Specific Enolase)
Use
Neuron Specific Enolase (NSE) is an immunohistochemical marker expressed in neurons and various neuroendocrine tissues. It helps detect tumors of neuroendocrine origin, including ganglioneuromas, neuroblastomas, Schwannomas, malignant melanomas, pheochromocytomas, paragangliomas, carcinoids, medullary thyroid carcinomas, pituitary adenomas, endocrine tumors of the pancreas and gastrointestinal tract, as well as neuroendocrine carcinoma of the skin (Merkel cell tumor) and small cell carcinoma of the lung. It assists pathologists in identifying neuroendocrine differentiation in tissue samples.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
NSE (Neuron Specific Enolase)
Protein
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred. Alternatively, one unbaked, unstained slide for H&E staining (required) plus two to three positively charged unstained slides, all cut at 4–5 microns.