P57, technical only
Use
p57 is a cyclin-dependent kinase inhibitor, cell cycle inhibitor, and tumor suppressor gene. Staining of p57 is used in the aid of differentiating complete hydatidiform mole (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole, in which both cytotrophoblasts and stromal cells stain. This test is technical only, and does not include a pathologist read.
Special Instructions
Not provided.
Limitations
The test does not include a pathologist interpretation; it is the technical component only. It is crucial that specimens are fixed in 10% NBF or B plus to avoid rejection. All other fixatives will lead to specimen rejection.
Methodology
Immunoassay (IHC)
Biomarkers
p57
Protein
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fixed (Non-FFPE))
Volume
Not provided
Minimum Volume
3-5 μM slides per stain (min 1 slide per stain)
Container
FFPE Block, Formalin Fixed
Collection Instructions
Fixative should be at a 20:1 fixative to tissue ratio, 10% neutral buffered formalin (NBF) for 6-72 hours (48-72 hours PREFERRED).
Storage Instructions
15°C to 25°C
Causes for Rejection
Specimens fixed in any fixative other than 10% NBF or B plus will be rejected.