p63 nuclear, technical only
Use
p63 is a transcription factor involved in regulating the development and differentiation of epithelial tissues. In pathology, p63 is widely used to identify squamous cell carcinoma and other epithelial tumors. p63 helps distinguish between squamous cell carcinomas and other malignancies, such as adenocarcinomas, and is particularly valuable in diagnosing and assessing tumors of the skin, breast, and head and neck.
Special Instructions
Not provided.
Limitations
The test is limited to the technical component of p63 staining only. It does not include pathologist interpretation or review, which must be conducted separately in conjunction with appropriate clinical and pathological evaluation.
Methodology
Immunoassay (IHC)
Biomarkers
p63
Protein
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fixed (Non-FFPE))
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Fresh tissues should be fixed with a 20:1 ratio of fixative to tissue in 10% neutral buffered formalin (NBF) for 6-72 hours, with 48-72 hours being preferred. Alternatively, specimens may be transferred to 70% ethanol for transportation after fixation.
Storage Instructions
Store at 15°C to 25°C. For longer term storage, specimens may be transferred to 70% ethanol and stored at 2-8°C.
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 Hours |