Podoplanin (D2-D40) Immunostain, Technical Component Only
Use
This test aids in the identification of reactive follicular dendritic cells. Podoplanin is a mucin-type transmembrane glycoprotein that is expressed in reactive follicular dendritic cells (FDC) and has been reported in FDC sarcomas. It is expressed in various tissues, including lymphatic endothelium, bile duct cells, mesothelial cells, ependyma, myoepithelial cells, and granulosa cells. The D2-40 antibody to podoplanin has been used in the diagnosis of mesothelioma and seminoma.
Special Instructions
Not provided.
Limitations
Age of a cut paraffin section can affect immunoreactivity, as stability thresholds vary widely and are antigen dependent. Best practice suggests paraffin sections be cut within 6 weeks. The charge of glass slides can be influenced by environmental factors, possibly affecting slide staining.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Podoplanin
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Attach the green 'Attention Pathology' address label and the pink Immunostain Technical Only label to the transport container.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides