Prostate Specific Antigen, Total with Reflex to Free PSA (Includes Free Percentage)
Also known as: TPSAR
Use
The Prostate Specific Antigen (PSA) test, performed using the Roche electrochemiluminescent immunoassay method, is an important tool for detecting prostate cancer when used alongside a digital rectal exam in individuals aged 50 and older. Elevated PSA levels can suggest the presence of prostate cancer, but biopsy is required for a definitive diagnosis. This test is also used for the prognosis and management of prostate cancer patients and can help distinguish between cancer and benign prostatic conditions.
Special Instructions
If the total PSA is between 3.0 to 10.0 ng/mL, Free PSA testing is automatically added, and additional charges apply. The Free PSA percentage is calculated to help differentiate prostate cancer from benign conditions.
Limitations
Results from different test methods or kits should not be used interchangeably. While this test aids in detecting prostate cancer and managing patients, elevated PSA levels alone cannot confirm the presence of cancer without a biopsy. PSA concentrations can also rise due to benign prostatic hyperplasia or inflammatory prostate conditions, and are typically not elevated in healthy individuals or those with non-prostatic carcinoma.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 2857-1
- 10886-0
- 12841-3
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect in a Serum Separator Tube (SST), Green (lithium heparin), Lavender (K2EDTA), or pink (K2EDTA). Allow specimen to clot at room temp and separate serum from cells ASAP or within 2 hours of collection.
Causes for Rejection
Grossly hemolyzed specimens, vaginal washings.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours |
| Refrigerated | 5 days |
| Frozen | 3 months |
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