Prostate Triple Stain
Use
The combination of p63 + CK HMW + P504S (PIN‑4 cocktail) is extremely useful for diagnosing prostatic intraepithelial neoplasia (PIN) and/or prostate carcinoma, particularly in challenging cases with limited tissue. P504S stains the cytoplasm red in prostate adenocarcinoma and atypical adenomatous hyperplasia, while p63 (nuclear brown) and high molecular weight cytokeratin (cytoplasmic brown) stain basal cells of normal and benign prostate glands, which are negative for malignant lesions.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
CK HMW
ProteinP504S
Proteinp63
Protein
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
A formalin‑fixed, paraffin‑embedded (FFPE) tissue block is preferred, or one unbaked, unstained slide for H&E staining (required) and two to three (2‑3) positively charged unstained slides cut at 4‑5 microns, with block and slide identifiers matching specimen ID on requisition.
Storage Instructions
Use cold pack for transport; ensure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.