Use

This test is used to evaluate protein S deficiency in patients with a personal or family history suggestive of hereditary thrombophilia. It confirms a diagnosis of autosomal dominant or autosomal recessive protein S deficiency by identifying disease-causing alterations in the PROS1 gene. Additionally, it is used for determining disease-causing alterations within the PROS1 gene to delineate the underlying molecular defect, assessing prognosis and risk based on genotype-phenotype correlations, and ascertaining the variant status of family members for clinical management and genetic counseling.