Q Fever Antibodies, IgG
Use
The Q Fever Antibodies, IgG test aids in the differential diagnosis of Q fever. It measures the presence of antibodies against Coxiella burnetii, the causative agent of Q fever, consequently helping clinicians determine exposure to the pathogen. The test evaluates the titer levels of both phase I and phase II antibody responses, which are critical for accurately identifying acute and chronic forms of Q fever, guiding effective treatment decisions.
Special Instructions
Four-fold increases in antibody titers between paired sera samples are recommended to demonstrate a recent infection. This test requires a serum sample, which should be stored at room temperature until it is tested. The proper collection container is a red-top tube or gel-barrier tube. Care should be taken to avoid sample rejection due to hemolysis, lipemia, or bacterial contamination.
Limitations
The Q Fever Antibodies, IgG test cannot distinguish between past and chronic infections solely based on IgG titers, and clinical correlation is necessary to interpret results accurately. False negatives may occur if samples are collected too early in the course of the disease, prior to seroconversion. Therefore, repeat testing may be warranted if Q fever is strongly suspected despite an initial negative result. Additionally, as with most serological tests, cross-reactivity with antibodies from other conditions or pathogens could potentially influence the outcome.
Methodology
Immunoassay (IFA)
Biomarkers
LOINC Codes
- 48719-9
- 48720-7
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.4 mL
Minimum Volume
0.2 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination
Other tests from different labs that may be relevant