RhC/c (RHCE) Antigen Genotyping

Casandra

Casandra Test Code AR20201Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3002002CPT Code 0001

RhC/c (RHCE) Antigen Genotyping

Also known as: RHC GENO

Clinical Use

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Use

RhC/c (RHCE) Antigen Genotyping is used to determine the RhC/c genotype of parental or neonatal individuals. This test is crucial for assessing the risk of alloimmune hemolytic disease, which can occur due to erythrocyte alloimmunization resulting in hemolytic transfusion reactions or hemolytic disease of the fetus and newborn (HDFN). By detecting the genotype, it can predict the expression of RhC or Rhc antigens, aiding in understanding the inheritance patterns and potential implications for offspring.

Special Instructions

Informed consent for genetic testing is required for patients residing in New York. Counselors recommend genetic counseling prior to testing. Consent forms are available online or through ARUP Client Services. Inconclusive results may occur in patients who have undergone hematopoietic stem cell transplants. Variations in the Rh locus may occasionally lead to indeterminate results.

Limitations

The assay may not detect rare nucleotide changes that result in altered or partial antigen expression, nor can it assess genotypes leading to Rh null phenotypes. False-negative results for RhC or Rhc predictions might occur due to RHCE-D-CE fusion genes. The assay is sometimes limited in predicting genotype due to extreme variation in the Rh locus, and abnormal signal intensities may also affect genotyping results.

Test Details

New York Approved