RhE/e (RHCE) Antigen Genotyping

Casandra

Casandra Test Code AR34675Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3002003CPT Code 0001

RhE/e (RHCE) Antigen Genotyping

Also known as: RHE GENO

Clinical Use

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Use

The RhE/e (RHCE) Antigen Genotyping test is used to determine the RhE/e genotype of a parental or neonatal sample. This test is crucial in assessing the risk of alloimmune hemolytic disease, which occurs due to erythrocyte alloimmunization. This can lead to hemolytic transfusion reactions or hemolytic disease of the fetus and newborn (HDFN). Understanding the RhE/e genotype helps in predicting the expression of Rh antigens, informing clinical decisions related to blood transfusions and maternal-fetal compatibility.

Special Instructions

Informed consent for genetic testing is required for New York patients. The test report provides a detailed interpretation, including genotype and predicted antigen expression. Any abnormal findings should be discussed with a genetic counselor. Consent forms are available online.

Limitations

The RhE/e (RHCE) Antigen Genotyping assay may not detect rare nucleotide changes that result in altered or partial antigen expression, nor null phenotypes. Extreme variation in the Rh locus can occasionally hinder genotype prediction. The test may produce false-negative results due to RHCE-D-CE fusion genes or inconclusive results in patients who have undergone hematopoietic stem cell transplants. Abnormal signal intensities might result in indeterminate genotyping results.

Test Details

FDA Approved