Saccharomyces cerevisiae Antibody, IgG, Serum
Use
This test measures IgG anti-Saccharomyces cerevisiae antibodies to aid in distinguishing between ulcerative colitis and Crohn disease, especially when the diagnosis is not clear from endoscopic, pathologic, and imaging evaluations. While this test is not useful in determining the extent of inflammatory bowel disease or in assessing the response to treatment, it helps differentiate the two main forms of inflammatory bowel disease: Crohn disease and ulcerative colitis.
Special Instructions
This test is best used when assessment in conjunction with antineutrophil cytoplasmic antibodies (ANCA). Some patients might have detectable antibodies that do not precisely fit one condition, as some Crohn disease patients may demonstrate ANCA and some ulcerative colitis patients may show IgA and/or IgG ASCA.
Limitations
Results from this test should not be used exclusively to diagnose ulcerative colitis or Crohn disease or to distinguish between these conditions. The presence of Saccharomyces cerevisiae antibodies is most beneficial for differentiation when used with ANCA results. Due to overlaps in antibody presence, some patients may have neither antibody or only one type, complicating diagnosis. Current guidelines do not recommend these antibodies for sole use in diagnosing inflammatory bowel diseases.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 47321-5
- 47321-5
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, Gross lipemia, Heat-treated specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 21 days |
| Frozen | 21 days |