Small Lymphocytic Lymphoma, FISH, Tissue
Use
This test is used for detecting recurrent common chromosome abnormalities in small lymphocytic lymphoma (SLL) using paraffin-embedded tissue specimens. It is particularly useful in distinguishing patients with 11;14 translocations who have mantle cell lymphoma from those with SLL. Additionally, it can identify patients with atypical SLL that involves translocations between IGH and BCL3. The assay's ability to detect these abnormalities aims to provide relevant prognostic information, though a positive result does not confirm SLL diagnosis.
Special Instructions
Not provided.
Limitations
This test is not approved by the FDA and should be used as an adjunct to clinical and pathologic information. Only formalin-fixed specimens are preferred; other fixative methods may be less successful but will not be rejected. Decalcified bone specimens have a success rate of about 50% for FISH analysis, and inadequate specimen may lead to test cancellation. Fish signals must be present post-hybridization to provide results, indicating sufficient tumor presence.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 103621-9 - SLL Bld/T FISH
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 93356-4 - Cells w cytogenetic abnl Bld/T
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 31208-2 - Specimen source
- 80398-1 - Unique ID Current sample
- 85069-3 - Lab test method
- 48767-8 - Annotation comment Imp
- 62364-5 - Test performance info Spec
- 18771-6 - Provider signing name
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Submit a formalin-fixed, paraffin-embedded tumor tissue block. Alternative fixation methods will be attempted but are less favorable. Include fixation method used.
Causes for Rejection
Non-formalin-fixed specimens, inadequate tumor presence