SOX-10 by Immunohistochemistry (Red Detection)
Also known as: SOX10R IHC
Use
Immunohistochemical stain used for detection of SOX‑10 expression in formalin‐fixed, paraffin‐embedded tissue sections. This stain is intended for clinical use as a technical stain and return service, without pathologist interpretation provided by ARUP, and is used to assist in identification of melanocytic and schwannian tumors. It is developed and validated by ARUP Laboratories in a CLIA‑certified laboratory as a laboratory‑developed test (LDT).
Special Instructions
Specimen must be formalin fixed (10% neutral buffered formalin) and paraffin embedded (cell block if applicable). Acceptable submission includes tissue block or at least five unstained, 3–5 micron thick, positively charged slides (minimum two slides). Slides should not be oven baked if precut. Recommended transport in tissue transport kit (ARUP supply #47808). The service is a stain and return (technical) service only. Ordering recommendation references ARUP Immunohistochemistry Stain Offerings brochure.
Limitations
Not cleared or approved by the U.S. Food and Drug Administration; performance is based on ARUP’s internal validation. Interpretation must be performed independently as ARUP does not provide pathologist interpretation. Specimen rejection may occur for non‑representative tissue or depleted specimens. Frozen specimens are unacceptable. Slides exposed to excessive heat or improperly prepared (e.g., oven baked precut slides) may compromise results.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 94736-6
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Tissue block or slides
Collection Instructions
Submit formalin-fixed, paraffin-embedded tissue block or at least five unstained (3‑ to 5‑micron thick) positively charged slides (minimum two slides). Do not oven bake if sending precut slides.
Storage Instructions
Transport at room temperature; refrigeration acceptable. Ship in cooled container during summer months.
Causes for Rejection
Non‑representative tissue type; depleted specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |
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