SS-B/La Antibodies, IgG, Serum

Casandra

Casandra Test Code MC17106Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID SSBCPT Code 86235

SS-B/La Antibodies, IgG, Serum

Clinical Use

Use

Evaluating patients with clinical features or at-risk for connective tissue disease, especially Sjögren syndrome. Anti-SS-B/La antibodies are primarily found in patients with SjS and, when present, can suggest a diagnosis of primary or secondary connective tissue disease if compatible autoantibody profile and clinical symptoms are present. The positive predictive value for primary Sjögren syndrome is increased with the positivity for antibodies to Ro52, Ro60, and SS-B/La. Combination of anti-SSB-B/A and anti-Ro52 and/or anti-Ro60 antibodies may also be useful in the phenotypic stratification of patients with primary Sjögren syndrome.

Special Instructions

For more information see Connective Tissue Disease Cascade. If not ordering electronically, complete, print, and send a Kidney Transplant Test Request with the specimen.

Limitations

Low levels and/or single positivity for anti-SS-B/La antibodies are likely to have limited clinical significance for the diagnosis and phenotypic stratification of patients with primary Sjögren syndrome. Unlike antibodies to SS-A/Ro that are present in SjS and other connective tissue diseases and primary biliary cholangitis, anti-SS-B/La antibodies have limited significant association without SS-A/Ro presence.

Test Details

FDA Approved