Streptococcus pneumoniae Antibodies, IgG (9 Serotypes)
Also known as: PNEUMO 9
Use
This test is used to evaluate antibody production and rule out antibody deficiency in patients vaccinated with Streptococcus pneumoniae vaccines such as Pneumovax (pure polysaccharide vaccine) or protein-conjugated vaccines like Prevnar and Vaxneuvance. It involves pre- and post-vaccination comparison to assess humoral immune response. An adequate immune response is determined based on the number of serotypes responded to within the vaccine challenge, which varies depending on the patient's age.
Special Instructions
Postimmunization specimens should be drawn 30 days after immunization and should be clearly marked as 'PRE' or 'POST'. They should be tested simultaneously if submitted separately. Shipping of postimmunization specimens must be within 60 days of preimmunization specimen collection. Testing is performed on Tuesdays and Fridays.
Limitations
Testing only postvaccination samples may provide a general immune status but may not adequately assess specific humoral immune response to the vaccines. Immune response can vary depending on the age, past exposure, immunocompetence, and specific pneumococcal serotype. Plasma or other body fluids, as well as contaminated, hemolyzed, or severely lipemic specimens, are not acceptable.
New York Approved
Methodology
Immunoassay (Multiplex Chemiluminescent)
Biomarkers
Concentration / Level
LOINC Codes
- 42771-6
- 86039-5
- 86098-1
- 86122-9
- 40973-0
- 86009-8
- 40974-8
- 86045-2
- 86052-8
- 40969-8
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.5 mL
Minimum Volume
0.25 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells within 2 hours of collection and transfer to ARUP standard transport tube. Mark specimens clearly as 'PRE' or 'POST'.
Storage Instructions
Refrigerated. Post-vaccination specimens received within 60 days of pre-vaccination sample.
Causes for Rejection
Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 60 days |
Other tests from different labs that may be relevant