Streptococcus pneumoniae Antigen, Spinal Fluid

Casandra

Casandra Test Code MC50109Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID SPNCCPT Code 87899

Streptococcus pneumoniae Antigen, Spinal Fluid

Clinical Use

Use

Streptococcus pneumoniae is the most frequently encountered bacterial agent of community-acquired pneumonia and can also cause bacterial meningitis. Rapid diagnosis of pneumococcal meningitis is crucial due to the associated significant morbidity and mortality. Antigen testing aids in the diagnosis when empirical antibiotics are being considered prior to culture confirmation. It provides a rapid diagnosis, aiding in the early management of pneumococcal infections.

Special Instructions

According to the College of American Pathologists (CAP Immunology Checklist, IMM.41830), cerebrospinal fluid (CSF) samples collected to make an initial diagnosis and submitted for detection of Streptococcus pneumoniae antigen testing should also be submitted for routine bacterial culture. Mayo Clinic Laboratories recommends that CSF bacterial cultures be performed at the originating site. If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.

Limitations

A negative result does not exclude Streptococcus pneumoniae infection. A diagnosis of Streptococcus pneumoniae infection must consider all test results, culture results, and the clinical presentation of the patient. Streptococcus pneumoniae vaccine may cause false-positive results, particularly in patients who received the vaccine within 5 days prior to specimen collection. This assay has not been validated for use with body fluids other than urine or cerebrospinal fluid. Performance has not been established for patients on antibiotic treatment for more than 24 hours.

Test Details

FDA Approved