T-Cell Acute Lymphoblastic Leukemia/Lymphoma (ALL), FISH, Adult, Varies
Use
This test is useful for detecting, at diagnosis, recurrent common chromosome abnormalities associated with T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) in adult patients using a laboratory-designated probe set algorithm. It serves as an adjunct to conventional chromosome studies in adult patients with T-ALL and evaluates specimens where chromosome studies are unsuccessful. Importantly, this test should not be used to screen for residual T-ALL.
Special Instructions
This test is performed only on samples from patients aged 31 years and older with T-cell acute lymphoblastic leukemia/lymphoma. If ordered for patients aged 30 years or younger, the test will be canceled and reordered as TALFP / Pediatric T-Lymphoblastic Leukemia/Lymphoma panel, FISH, Varies. For patients on a Children's Oncology Group (COG) protocol, the test will be canceled and reordered as COGTF. Avoid duplicate testing by following these guidelines.
Limitations
This test was developed according to CLIA requirements and is not FDA-approved. It should not replace conventional chromosome studies, which detect additional abnormalities associated with other hematologic disorders. FISH results may not detect all chromosomal abnormalities in T-ALL. Lack of FISH results can occur if no FISH signals are observed post-hybridization.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 101663-3
- 50397-9
- 69965-2
- 93356-4
- 62356-1
- 42349-1
- 31208-2
- 85069-3
- 48767-8
- 62364-5
- 18771-6
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 to 3 mL
Minimum Volume
1 mL
Container
Yellow top (ACD); Green top (sodium heparin) or lavender top (EDTA) acceptable
Collection Instructions
It is preferable to send the first aspirate from the bone marrow collection. Invert several times to mix bone marrow. Send bone marrow specimen in original tube. Do not aliquot.