T-Cell Lymphoma, FISH, Tissue
Use
This test is useful for detecting recurrent common chromosome abnormalities in various T-cell lymphomas at diagnosis. It provides prognostic information for patients with documented systemic ALK-negative anaplastic large cell lymphoma. The test is used to evaluate paraffin-embedded tissue specimens, employing different probe sets according to the suspected lymphoma subtype, the patient's age, and clinical questions. The test aids in diagnosing T-cell lymphomas and contributes to determining the subtype and prognosis based on chromosome abnormalities detected.
Special Instructions
Not provided.
Limitations
The assay detects chromosome abnormalities in paraffin-embedded tissue samples; it will be canceled if non-paraffin embedded bone marrow or blood samples are received. Alternative fixation methods may be less favorable for successful results. Non-formalin-fixed tissues aren't rejected, but reliability decreases. Paraffin-embedded tissues that have been decalcified have about a 50% success rate in FISH analysis. Lack of sufficient representative cells prevents analysis, incurring no analysis charges. The absence of detected abnormalities doesn't rule out a neoplastic disorder or affect the pathological diagnosis.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 101682-3 - T-cell lymphoma Bld/T Doc FISH
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 93356-4 - Cells w cytogenetic abnl Bld/T
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 31208-2 - Specimen source
- 80398-1 - Unique ID Current sample
- 85069-3 - Lab test method
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Formalin-fixed, paraffin-embedded tumor tissue block
Collection Instructions
Submit a tissue block prepared with formalin fixation. Provide the fixation method used. Include 1 hematoxylin and eosin-stained slide and 2 unstained slides for each probe set.
Storage Instructions
Ambient preferred, or refrigerated