T-Cell Receptor Gene Rearrangements Profile, γ and β

Casandra

Casandra Test Code LC26317Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 481080CPT Codes 81340, 81342

T-Cell Receptor Gene Rearrangements Profile, γ and β

Also known as: TCRB Gene Clonality Assay, TCRG Gene Clonality Assay

Clinical Use

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Use

This profile can be used to detect clonal T-cell receptor γ-chain (TCRG) and β-chain (TCRB) gene rearrangements in blood, bone marrow, and tissue specimens with a combined T-cell clonality detection rate of 94% to 99%. The presence of a monoclonal gene rearrangement usually, but not always, reflects the presence of a T-lymphocytic neoplasm, while polyclonal gene rearrangement patterns are found in benign reactive conditions. Thus, the results of these studies can assist in the diagnosis of lymphoproliferative disorders.

Special Instructions

Please direct any questions regarding this test to customer service at 800-345-4363.

Limitations

The PCR assay detects a clonal DNA population at a sensitivity of 5% in a background of polyclonal DNA. It may not detect all possible T-cell receptor gene rearrangements. The test is not cleared or approved by the FDA, and additional time may be required for confirmatory tests.

Test Details