Thyroglobulin Immunostain, Technical Component Only
Use
Thyroglobulin is a glycoprotein produced by thyroid epithelial cells that bind with iodine to form thyroid hormone in the blood. Staining with thyroglobulin antibody is instrumental in classifying poorly differentiated or metastatic thyroid carcinomas, allowing for precise identification and differentiation.
Special Instructions
Not provided.
Limitations
The age of a cut paraffin section can influence immunoreactivity, and the stability thresholds of such sections vary depending on the antigen, as extensively noted in the literature. Optimal practice dictates cutting paraffin sections within six weeks of examination. Additionally, the surface chemistry of slides, particularly positively charged slides, is susceptible to alterations due to environmental exposure, resulting in potential staining inconsistencies.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Thyroglobulin
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Formalin-fixed, paraffin-embedded tissue block or 2 unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.
Storage Instructions
Ambient (preferred) or refrigerated.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged or special slides like ProbeOn/Snowcoat.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Best practice is not to exceed six weeks after sectioning. |