Thyroglobulin, Interference Interpretation
Use
The Thyroglobulin, Interference Interpretation test is useful for evaluating suspected interference in thyroglobulin measurements caused by heterophile antibodies. These interferences can result in falsely elevated thyroglobulin levels, which could lead to a misinterpretation of a patient's disease state, particularly in the follow-up of differentiated thyroid carcinoma. Accurate interpretation of thyroglobulin levels is crucial for effective patient management, and this test helps differentiate whether heterophile antibody interference is affecting the results.
Special Instructions
This test is only orderable as part of a profile, specifically the Interference Evaluation Heterophile, Thyroglobulin Tumor Marker, Serum profile. The evaluation includes pretreatment with commercial heterophile antibody blocking reagents, serial dilutions, and testing on an alternate platform to identify interferences.
Limitations
This evaluation does not rule out the presence of other interfering substances such as biotin. Strong heterophile interference might not be fully blocked by blocking reagents, leading to continued interference in results. Also, thyroglobulin levels determined by different assay methods vary and cannot be compared directly. A falsely low result may occur if variations in the amino acid sequence of thyroglobulin coincide with tryptic peptides used in MS analysis.
New York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 101626-0
- 101627-8
- 101628-6
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
Not provided
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 90 days |