TPMT Enzyme
Use
PROMETHEUS TPMT Enzyme testing provides a quantitative analysis of a patient’s thiopurine methyltransferase (TPMT) enzyme activity level. The test is essential for phenotyping a patient to aid in individualizing a starting dose of thiopurines. The efficacy and toxicity of thiopurines can vary widely among patients, and knowledge of the TPMT enzyme phenotype may reduce time to response, allow physicians to individualize dosing, identify patients in whom thiopurine therapy should be avoided, and help reduce the risk of leukopenia.
Special Instructions
Performed exclusively at Prometheus Laboratories Inc., a clinical reference laboratory in San Diego. As a laboratory-developed test, it has not been FDA cleared or approved. The test is CLIA certified and CAP accredited.
Limitations
Currently, FDA approval is not required for testing performed by Prometheus. Laboratory testing considered experimental by some insurance providers. This limitation may affect insurance coverage policies.
Methodology
Other
Biomarkers
Result Turnaround Time
3 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5.0 mL
Minimum Volume
Not provided
Container
EDTA/Lavender-Top Tube
Storage Instructions
Cold pack preferred, do not freeze
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 8 days |
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