Tree Panel #1, Serum

Casandra

Casandra Test Code MC24724Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID TREE1CPT Code 86003

Clinical Use

Use

The test is useful for establishing a diagnosis of an allergy to trees included in panel #1 and for defining the allergens responsible for eliciting signs and symptoms in patients. It identifies allergens responsible for allergic responses and confirms sensitization before beginning immunotherapy. In addition, the test investigates the specificity of allergic reactions to certain allergens, such as insect venom allergens, drugs, or chemical allergens. It is not useful for determining residual clinical sensitivity in patients previously treated with immunotherapy or when medical management does not depend on the identification of allergen specificity.

Special Instructions

This multi-allergen IgE antibody panel, combined with IgE measurement in serum, acts as a first-order test for allergic disease. The test is cost-effective and requires less specimen volume, but it does not identify individual allergen responses. If a positive result is obtained, follow-up testing is necessary to differentiate among the individual allergens within the panel. Testing is performed by fluorescence enzyme immunoassay (FEIA).

Limitations

Testing for IgE antibodies may yield false-positive results due to nonspecific binding in cases of elevated serum IgE levels (>2500 kU/L). Single allergen responses cannot be identified from the test panel; further testing is necessary if the result is positive to specify the responsible allergen. The test result interpretation should be made in the full clinical context, as some individuals may show levels of IgE antibodies with no significant clinical allergy.

Test Details

New York Approved