Special Instructions

A hereditary cancer clinical questionnaire should be submitted with all specimens. Contact CMBP genetic services at 800-345-4363 to coordinate testing. To order Oragene Dx 500 saliva collection kits using PeopleSoft No. 87917, contact your local Labcorp branch supply department.

Limitations

Sequencing cannot detect variants in regions not covered by this analysis, including noncoding or deep intronic variants. It may not reliably detect changes in repetitive elements, such as microsatellite repeats, nor can it detect mosaic variants, inversions or other genomic rearrangements such as transposable element insertions. This assay cannot determine whether two heterozygous variants are present on the same or different chromosome copies. Copy number analyses may miss certain genomic rearrangements like translocations, inversions, or some partial exon rearrangements. Pseudogenes can interfere with variant detection in some genes, and the presence of pseudogenes like PMS2CL can complicate deletion/duplication analysis. This test is not intended to detect somatic variants, and previous bone marrow transplantation may affect results. This assay has not been cleared or approved by the FDA.

Biomarkers

LOINC Codes

Result Turnaround Time

Related Documents

Stability Requirements