Vitamin B12 and Folates

Casandra

Casandra Test Code LC55581Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 000810CPT Codes 82607, 82746

Vitamin B12 and Folates

Clinical Use

Use

The Vitamin B12 and Folates test is essential for diagnosing deficiencies in Vitamin B12 and folic acid, which are critical for maintaining healthy nerve cells and producing DNA and RNA. Deficiencies can result in megaloblastic anemia and other neurological disorders. The test is particularly significant in identifying the cause of anemia and assessing individuals with malabsorption disorders, vegan diets, or those on long-term antacid therapy, which may lead to deficiencies.

Special Instructions

This test may exhibit interference if the sample is collected from individuals consuming high doses of biotin supplements. Biotin is also known as Vitamin B7, B8, Vitamin H, or coenzyme R. It is recommended to advise patients to stop biotin intake at least 72 hours before sample collection to avoid test interference.

Limitations

While this test accurately measures Vitamin B12 and folate levels, it may not detect all conditions associated with deficiencies or excess of these vitamins. Factors such as liver disease, myeloproliferative disorders, and certain medications may also affect levels, leading to incorrect interpretations. Additionally, this test might not reflect recent changes in diet or supplementation since serum levels can fluctuate. Caution is advised when interpreting results from patients with recent changes in dietary intake or supplement regimen.

Test Details