von Willebrand Disease Profile Technical Interpretation

Casandra

Casandra Test Code MC52058Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID AVWPICPT Code 85390

von Willebrand Disease Profile Technical Interpretation

Clinical Use

Use

The technical interpretation of the von Willebrand factor profile test is vital for detecting deficiencies or abnormalities in von Willebrand factor (VWF), which plays a crucial role in blood coagulation. This test assists in identifying subtypes of von Willebrand disease (VWD), such as type 1, type 2 variants, or type 3. Type 1 is the most common, while type 3 is rare. It helps in the clinical management of bleeding disorders by providing detailed insights into VWF functionality and its interactions with factor VIII, which are critical in forming hemostatic plugs and stabilizing blood clots.

Special Instructions

This test is part of a profile and not available as a standalone order. It is essential for comprehensive assessment and should be part of the von Willebrand Disease Profile, Plasma. Testing should be coordinated with patient history and possibly repeated to confirm low VWF levels, especially in cases of strong clinical suspicion of VWD.

Limitations

This test is not useful for detecting hemophilia carriers or differentiating between type 2A and 2B VWD or platelet-type VWD, which requires additional testing like ristocetin-induced platelet aggregation. Low normal levels of VWF antigen or activity do not exclude VWD, and repeat testing may be needed for diagnosis confirmation, particularly in cases of mild type 1 VWD. It should be noted that external conditions such as recent transfusion, therapy, or use of estrogens can affect VWF levels.

Test Details

New York Approved