Zinc Protoporphyrin (ZPP)
Also known as: ZPP, Protoporphyrin, Zinc, Free Erythrocyte Protoporphyrin
Use
Zinc protoporphyrin (ZPP) accumulates in erythrocytes as a result of chronic lead absorption or iron deficiency anemia. Measurement is commonly used in screening for lead exposure and in evaluation of anemia. Aluminum and anemia of chronic disease may also cause elevated results, and ZPP is not recommended for monitoring acute intermittent porphyria.
Special Instructions
Use a lead‑free tube if blood lead is also requested. Specimen must be protected from light. This test was developed by Quest Diagnostics; it has not been cleared or approved by the U.S. Food and Drug Administration. It has been validated under CLIA regulations and is used for clinical purposes. Set up occurs Monday–Saturday; report available in 1–2 days.
Limitations
Aluminum and anemia of chronic disease may cause elevated results. Hemolysis, frozen or clotted specimens, and EDTA (lavender‑top) tube use can invalidate the test.
Methodology
Other
Biomarkers
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
2 mL (0.5 mL minimum; pediatric 0.2 mL minimum)
Minimum Volume
0.5 mL (pediatric 0.2 mL)
Container
EDTA‑light protected (tan‑top) tube; acceptable: sodium heparin (royal blue or green‑top) tube or lithium heparin (green‑top) tube
Collection Instructions
Use a lead‑free tube if blood lead is also requested; protect specimen from light
Causes for Rejection
Hemolysis; received frozen; clotted; EDTA (lavender‑top) tube
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 10 days |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant