Zonisamide
Also known as: ZONI
Use
Zonisamide testing is crucial for optimizing drug therapy and monitoring patient adherence in individuals undergoing treatment with this anticonvulsant medication. Regular monitoring of zonisamide blood levels helps ensure therapeutic effectiveness while minimizing toxicity and adverse effects. The test is particularly important for managing patients with co-medications or compromised renal function, as pharmacokinetics can vary widely in these populations.
Special Instructions
Not provided.
Limitations
The therapeutic range for zonisamide is not well established, making it imperative to correlate test results with clinical findings. Toxic concentrations exceeding 80 µg/mL can lead to severe conditions such as coma, seizures, and cardiac anomalies. Additionally, factors such as other medications and renal function can significantly influence zonisamide levels, necessitating careful interpretation of test outcomes in certain patient scenarios.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Other)
Biomarkers
Zonisamide
Analyte
LOINC Codes
- 29620-2 - Zonisamide SerPl-mCnc
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect pre-dose (trough) draw at steady state concentration in plain red, lavender (K2 or K3EDTA), or pink (K2 EDTA) tube. Separate serum or plasma from cells within 2 hours of collection.
Storage Instructions
Refrigerated
Causes for Rejection
Whole blood, gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 1 week |
| Frozen | 6 weeks |
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