17-Hydroxyprogesterone Quantitative by HPLC-MS/MS, Serum or Plasma
Also known as: OHPRGSTON
Use
The 17-Hydroxyprogesterone Quantitative by HPLC-MS/MS test is clinically significant for evaluating 21-Hydroxylase Deficiency, a common cause of Congenital Adrenal Hyperplasia (21-OHD CAH). It also plays a crucial role in diagnosing Polycystic Ovary Syndrome (PCOS) and adrenal insufficiency. This test assists in the diagnosis and management of these conditions by measuring the levels of 17-Hydroxyprogesterone, a steroid hormone produced during the synthesis of cortisol. Variations in 17-Hydroxyprogesterone levels may indicate a hormonal imbalance or enzyme deficiency impacting adrenal steroidogenesis.
Special Instructions
Not provided.
Limitations
The test may be affected by hemolyzed specimens, which are considered unacceptable conditions for testing. It is crucial to follow the specimen preparation instructions meticulously to avoid interference from other substances or poor specimen quality that could lead to inaccurate results. Furthermore, while the test provides quantitative data on 17-Hydroxyprogesterone levels, it does not specify the exact cause of hormonal imbalances or enzyme deficiencies, necessitating further testing for differential diagnosis.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
17-Hydroxyprogesterone
Analyte
LOINC Codes
- 1668-3 - 17OHP SerPl-mCnc
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Serum separator tube (SST), Plain red, pink (K2EDTA), plasma separator tube (PST), green (sodium heparin), or green (lithium heparin)
Collection Instructions
Collect using the specified tubes. Transfer the required volume to an ARUP standard transport tube.
Storage Instructions
Transport Frozen. Also acceptable: Refrigerated.
Causes for Rejection
Grossly hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 3 Days |
| Refrigerated | 1 week |
| Frozen | 6 months |
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