Alpha Beta Double Negative T-Cells for Autoimmune Lymphoproliferative Syndrome

Casandra

Casandra Test Code AR55733Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 2014513CPT Code 86356

Alpha Beta Double Negative T-Cells for Autoimmune Lymphoproliferative Syndrome

Also known as: ALPS ABDNT

Clinical Use

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Use

This test aids in the diagnosis of autoimmune lymphoproliferative syndrome (ALPS), which is characterized by an increased concentration of CD3+ T-cells that are negative for CD4 and CD8 (double-negative T-cells [DNT]) and positive for the alpha/beta T-cell receptor (TCR). B220 expression on alpha/beta TCR+DNT cells is used as a sensitive and specific marker for ALPS, which is often associated with mutations in the FAS gene. Abnormal results should be correlated with clinical history and confirmed by additional testing.

Special Instructions

Not provided.

Limitations

The test is not approved by the US Food and Drug Administration; it was developed and its performance characteristics were determined by ARUP Laboratories. This test is intended for clinical purposes and is performed in a CLIA-certified laboratory. The results must be interpreted in the context of the patient's clinical history and correlated with other testing for mutations in the FAS gene and defective in vitro lymphocyte apoptosis.

Test Details