Amiodarone and Metabolite
Also known as: AMIOD
Use
This test is utilized for optimizing drug therapy and monitoring patient adherence for individuals on amiodarone treatment. It provides quantitative measurements of both amiodarone and its active metabolite, N-desethylamiodarone, which helps in assessing therapeutic levels and potential toxicity. The test specifically aids in identifying toxic concentrations that might exacerbate arrhythmias and cause liver, lung, and thyroid dysfunction. Monitoring these levels enables healthcare providers to tailor therapy effectively and prevent possible adverse effects.
Special Instructions
Timing of specimen collection is crucial and should be done as a predose (trough) draw at steady state concentration. Proper collection and handling of specimens are important, requiring immediate separation of serum or plasma from cells and freezing to protect from degradation.
Limitations
The concentration of desethylamiodarone is reported, but no established therapeutic range exists for this metabolite. Interpretation of results should consider that the metabolite concentration can be similar to the amiodarone concentration at steady state, necessitating careful clinical correlation. This test does not differentiate between different potential underlying causes of toxicity or adverse effects.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
Result Turnaround Time
1-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP amber standard transport tube
Collection Instructions
Transfer serum or plasma to container immediately after separation.
Patient Preparation
Predose (trough) draw at steady state concentration.
Storage Instructions
Freeze immediately to protect from light.
Causes for Rejection
Whole blood, gel separator tubes, blue or yellow tubes, refrigerated or room temperature specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | Unacceptable |
| Frozen | 1 year |