ANCA-Associated Vasculitis Profile (ANCA/MPO/PR3)
Also known as: ANCA-PRO
Use
The ANCA-Associated Vasculitis Profile is a comprehensive panel used for evaluating ANCA-associated vasculitis, a condition characterized by the presence of antineutrophil cytoplasmic antibodies (ANCA) that target specific antigens in the neutrophil cytoplasm. This test includes measurements of Myeloperoxidase (MPO) Antibody and Serine Proteinase 3 (PR3) Antibody. It helps to differentiate between the patterns of ANCA associated with various vasculitic disorders. This panel is crucial for diagnosing and managing patients suspected of having ANCA-associated vasculitis and informs treatment decisions.
Special Instructions
Not provided.
Limitations
The test cannot be performed on CSF, plasma, urine, or other body fluids and is limited by sample condition; contaminated, hemolyzed, or severely lipemic specimens are unacceptable. Specificity and sensitivity for detecting ANCA, MPO, and PR3 are limited by serum antibody concentrations and may not detect low levels in certain individuals. ANCA patterns identified by IFA may not specify the exact antigen associated with vasculitis; however, they can aid in determining the likelihood of disease presence when used in conjunction with other clinical findings.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 6969-0 - Myeloperoxidase Ab Ser-aCnc
- 6968-2 - Proteinase3 Ab Ser-aCnc
- 21419-7 - ANCA Ab pattern Ser IF-Imp
- 29967-7 - ANCA IgG Titr Ser IF
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection and transfer to a transport tube.
Storage Instructions
Refrigerated.
Causes for Rejection
CSF, plasma, urine, or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 30 days (avoid repeated freeze/thaw cycles) |
Other tests from different labs that may be relevant