Aquaporin-4 (AQP4) Antibody, IgG by CBA-IFA With Reflex to Titer, CSF
Also known as: AQP4 CSF
Use
Useful in the initial evaluation of neuromyelitis optica (NMO) spectrum disorders. Approximately 75% of patients with NMO have antibodies to the aquaporin-4 (AQP4) receptor. While the absence of AQP4 receptor antibodies does not rule out a diagnosis of NMO, presence of this antibody is diagnostic for NMO. This indirect fluorescent antibody assay utilizes AQP4 receptor transfected cell lines for the detection and semiquantification of AQP4 IgG antibody.
Special Instructions
Not provided.
Limitations
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
New York Approved
Methodology
Cell-based / Cytometry
Biomarkers
Aquaporin-4 Receptor
Protein
LOINC Codes
- 46718-3 - AQP4 H2O channel IgG CSF Ql
Result Turnaround Time
1-6 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
0.5 mL
Minimum Volume
0.15 mL
Container
ARUP standard transport tube
Storage Instructions
Refrigerated
Causes for Rejection
Hemolyzed, contaminated specimens or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month |
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