Arbovirus Antibodies, IgG, CSF
Also known as: ARBO CSF G
Use
This test is used for the detection of IgG antibodies against arboviruses such as West Nile Virus, California Encephalitis, St. Louis Encephalitis, Eastern Equine Encephalitis, and Western Equine Encephalitis in CSF samples. The presence of IgG antibodies may suggest a current or past infection with these viruses, indicating potential central nervous system infection. The test is performed using semi-quantitative indirect fluorescent antibody (IFA) and enzyme-linked immunosorbent assay (ELISA) methods. Clinical correlation and additional testing may be necessary due to the potential for cross-reactivity with other viruses within the Flaviviridae and Alphavirus families.
Special Instructions
Not provided.
Limitations
The test should not be used solely for quantitative purposes and must be interpreted in conjunction with clinical history and other data. Cross-reactivity with other members of the Flaviviridae and Alphavirus families can occur, which may necessitate serologic testing specific for these species. The detection of antibodies in CSF may be influenced by contamination with blood or transfer of antibodies across the blood-brain barrier, which must be considered.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 39572-3 - WNV IgG CSF IA-aCnc
- 49138-1 - CEV IgG Titr CSF IF
- 21509-5 - SLEV IgG Titr CSF IF
- 10897-7 - EEEV IgG Titr CSF IF
- 9315-3 - WEEV IgG Titr CSF IF
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
4 mL
Minimum Volume
1.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Transfer 4 mL CSF to an ARUP Standard Transport Tube. For New York State clients, 1 mL CSF (Min: 0.1 mL) AND CSF 2 mL (Min: 0.7 mL) required.
Storage Instructions
Refrigerated. New York State Clients: Frozen.
Causes for Rejection
Plasma, contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours (New York State: 4 days) |
| Refrigerated | 2 weeks (New York State: 1 week) |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) (New York State: 1 month) |
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