Autoimmune Neuromuscular Junction Reflexive Panel
Also known as: MUWA R2
Use
The Autoimmune Neuromuscular Junction Reflexive Panel aids in diagnosing a broad range of acquired neuromuscular junction (NMJ) disorders. It is particularly useful for the evaluation of myasthenia gravis and other autoimmune diseases affecting the neuromuscular junction, such as Lambert-Eaton myasthenic syndrome and autoimmune autonomic ganglionopathy. The test includes various antibodies associated with these disorders, helping identify autoimmune involvement and assist in differential diagnosis.
Special Instructions
If the Acetylcholine Receptor Binding Antibody result is greater than 0.4 nmol/L or the Acetylcholine Receptor Blocking Antibody result is greater than 26 percent, Acetylcholine Receptor Modulating Antibody will be added. If Striated Muscle Antibodies are detected, a titer will be added. If Voltage-Gated Potassium Channel antibodies are Indeterminate or Positive, LGI1 and CASPR2 antibodies will be added. Additional charges apply for reflex tests.
Limitations
This test was developed and its performance characteristics determined by ARUP Laboratories. It is intended for clinical purposes and has not been cleared or approved by the US Food and Drug Administration. Antibodies to other neuromuscular junction proteins may result in negative test results. Interpretation should be made in conjunction with clinical history and other diagnostic tests to accurately diagnose NMJ disorders.
New York Approved
Methodology
Immunoassay (Radioimmunoassay)
Biomarkers
LOINC Codes
- 49692-7
- 11034-6
- 33980-4
- 42937-3
- 41871-5
- 100371-4
- 33979-6
- 42233-7
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Serum separator tube (SST)
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Transport refrigerated.
Causes for Rejection
Plasma. Contaminated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |