Babesia microti Antibodies, IgG and IgM by IFA

Also known as: BAB MIC AB

Clinical Use

Use

The Babesia microti Antibodies, IgG and IgM by IFA test is primarily used when a Giemsa stain is negative but a high suspicion of babesiosis exists. The test is designed to detect antibodies against Babesia microti specifically, without cross-detecting B. duncani or strain MO-1. Babesia microti infection can lead to babesiosis, a malaria-like disease. Detecting these antibodies at certain levels can indicate either a current or past infection, providing crucial information for diagnosis and management of the disease. Negative results may not necessarily rule out infection during an acute phase, making clinical correlation necessary.

Special Instructions

Not provided.

Limitations

The test will not detect B. duncani or strain MO-1, limiting its scope to Babesia microti. False negatives may occur, especially if the patient is tested too early in the course of infection. Specimens that are bacterially contaminated, hemolyzed, or lipemic are unacceptable and can affect the accuracy of the test results. The test methodology involves semi-quantitative indirect fluorescent antibody (IFA) assessment, and results depend on serum stability and proper specimen handling. Repeated freeze/thaw cycles should be avoided as they may impact the functionality and quantitation of antibodies.

Test Details

New York Approved

Methodology

Immunoassay (Other)

Biomarkers

2 components

Babesia microti IgG Antibody Test • OtherBabesia microti IgM Antibody Test • Other

LOINC Codes

Result Codes

16117-4 - B microti IgG Titr Ser
16118-2 - B microti IgM Titr Ser

Result Turnaround Time

1-5 days

Specimen

Serum

Volume

1 mL

Minimum Volume

0.4 mL

Container

Serum Separator Tube (SST)

Collection Instructions

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. Mark specimens as 'acute' or 'convalescent.'