C5 Inhibitors Drug Monitoring Panel
Also known as: C5 INH PAN
Use
Use to monitor complement blockage in patients treated with C5 inhibitor drugs. The panel is designed to assess complement functional assay activity (CH50), alternative pathway functional assay (AH50), and C5 functional assay. Monitoring these parameters ensures effective complement blockade and aids in evaluating treatment efficacy. Decreases in complement parameters may suggest inadequate complement inhibition or secondary consumption of components.
Special Instructions
Separate serum from cells as soon as possible or within 2 hours of collection. Transfer 2.0 mL of serum to an ARUP standard transport tube and freeze immediately. Specimens should be frozen critically, and separate specimens must be submitted when multiple tests are ordered.
Limitations
The panel may show decreased or absent activity in functional assays while normal or elevated C5 protein concentrations are present. The results are subject to variability due to in vitro complement activation and component consumption due to collection, transport, and handling conditions. In cases of unexpected results, repeat testing with fresh frozen serum is suggested for verification.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 4505-4
- 74520-8
- 4532-8
- 60472-8
- 48767-8
Result Turnaround Time
1-9 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2.0 mL
Minimum Volume
2.0 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Freeze immediately.
Storage Instructions
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Causes for Rejection
Specimens received refrigerated, ambient, lipemic, or grossly hemolyzed. Serum separator tubes. Specimens collected using calcium-binding anticoagulants (i.e., EDTA, ACD).