Angioedema Panel, Hereditary, Comprehensive
Also known as: C1 Esterase Inhibitor Profile
Use
This panel is designed to assist in the diagnosis of hereditary angioedema (HAE) by measuring key complement factors including C1 esterase inhibitor functional activity, C1 esterase inhibitor protein level, and complement component C4c. It facilitates differentiation of HAE subtypes and supports clinical evaluation in patients with recurrent angioedema episodes without urticaria, enabling more accurate diagnosis and management.
Special Instructions
Not provided.
Limitations
Patients taking anabolic steroids may have falsely elevated C4 values.
Methodology
Immunoassay (Nephelometry)
Biomarkers
C1 Esterase Inhibitor, Functional
ProteinC1 Esterase Inhibitor, Protein
ProteinComplement Component C4c
Protein
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1.2 mL
Container
Plastic screw-cap vial (red-top tube with no gel)
Collection Instructions
Freeze serum within one hour of collection. Do not submit the sample in a glass tube. Do not thaw.
Patient Preparation
Overnight fasting is preferred
Causes for Rejection
Lipemia • Received at room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | Unacceptable |
| Frozen | 21 days |
Other tests from different labs that may be relevant